Cosmo Bio Co., Ltd.

Seeking for EU partner interested in

a.) mass production of useful recombinant protein expression using genome-edited transgenic chicken egg bioreactor

b.) licensing in exosome recognizing novel antibodies

c.) Peptide Discovery Service from MeSCue-Janusys Inc. (Japan)

KEY ACTIVITIES Drug discovery support and contract services
SECTOR: Biotech & Life Science
KEY WORDS: Recombinant protein expression, Exosome / Extracellular vesicles (EVs), Antibodies, Peptide Discovery Service
TYPE OF ACTIVITIES Manufacturing/Services provider

Company Description:

They offer contract manufacturing service for mass production of useful recombinant proteins using chicken egg bioreactor. Technology allows to stably produce large amount of useful recombinant proteins of your interest in egg whites of genome-edited transgenic chicken eggs, which results to extreme cost reduction of the production.

 

They also offer licensing in of their exosome surface protein recognizing antibodies for your research & commercial use (CD9 [clone 12A12], CD63 [clone 8A12], CD81 [clone 12C4]). These antibodies are being used as a golden standard of exosome researches in Japan. Get great discounts for bulk orders on any of these antibodies by contacting them directly.

 

They offer Peptide Discovery Service from MeSCue-Janusys Inc. (Japan). Service offers you with peptide candidates those bind with your desired cell surface target molecules. As one of the most expensive pharmaceutical agents are antibody drugs, MeSCue-Jenusys is focusing on replacing antibody drugs to peptide drugs.

 

Type of Partnership Sought:

1. Manufacturing agreement
2. License agreement
3. Services agreement
4. Subcontracting

 

Additional information:

Recombinant protein expression service with “All Japan” production technologies using genome-edited transgenic chicken. This manufacturing service is performed under licenses from National Institute of Advanced Industrial Science and Technology (AIST), National Agriculture and Food Research Organization (NARO) and C4U Corporation.

 

MASS PRODUCTION OF USEFUL RECOMBINANT PROTEINS USING GENOME-EDITED TRANSGENIC CHICKEN EGG BIOREACTOR

Service flow

 

1. Introduce gene of your interest into primordial germ cells (PGSs) using novel genome-editing & transgenic technology (CRISPR-Cas3 1)).

 

2. Breed genome-edited rooster (G0) with wild-type hen.

 

3. Protein of your interest to be expressed in Hen (G1) egg white, followed by the egg white separation process. We will satisfy each client needs for deliverable.

 * Rooster (G1) carrying gene of your interest will be bred to keep the strain, to stably provide you with the protein of interest.

 

Example case studies 2)

  • Human cytokines (in-house development)
  • Humanized antibodies
  • Industrial use protein  

etc.

 

References

1) CRISPR/Cas3 technology
Morisaka, H., Yoshimi, K., Okuzaki, Y. et al. CRISPR-Cas3 induces broad and unidirectional genome editing in human cells. Nat Commun 10, 5302 (2019). https://doi.org/10.1038/s41467-019-13226-x

2) Chicken egg bioreactor case studies
 CRISPR/Cas9 technology
Oishi, I., Yoshii, K., Miyahara, D. et al. Efficient production of human interferon beta in the white of eggs from ovalbumin gene–targeted hens. Sci Rep 8, 10203 (2018). https://doi.org/10.1038/s41598-018-28438-2

 

 

LICENSING IN OF THEIR EXOSOME SURFACE PROTEIN RECOGNIZING ANTIBODIES FOR YOUR RESEARCH & COMMERCIAL USE  (CD9 [CLONE 12A12], CD63 [CLONE 8A12], CD81 [CLONE 12C4])

They obtained hybridoma cell lines expressing monoclonal antibodies against exosome surface proteins (CD9, CD63, CD81, respectively) from Shionogi Pharmaceutical, including relating patents for diagnostics use of these antibodies.

 

 

DE NOVO PEPTIDE DISCOVERY SERVICE BY CONSTRUCTING PEPTIDE LIBRARY

Features

  • Construct peptide libraries using cDNA display method.
    → Achieve 1 -1013 kinds of enormous diversity.
  • Superior technique that possesses various features for peptide library construction.
    → Enhanced safety and improved target specificity by utilizing circular peptide library.
  • Application for acquire peptide against cell surface target molecules.
    → Feature of cDNA display technique (high stability) make it possible to select cell surface target molecules.


Fig.1 Schematic procedure for peptide acquisition by cDNA display technique.

 

Company website